| Darrelle Revis | Aliquippa | New York Jets |
| Jon Baldwin | Aliquippa | Kansas City |
| Tommie Campbell | Aliquippa | Tennessee |
| Jason Pinkston | Baldwin | Cleveland |
| Andrew Hawkins | Bishop McCort | Cincinnati |
| Aaron Berry | Bishop McDevitt | New York Jets |
| LeSean McCoy | Bishop McDevitt | Philadelphia |
| Anthony Walters | Cardinal O’Hara | Chicago |
| Bryan Scott | Central Bucks East | Buffalo |
| Robbie Gould | Central Mountain | Chicago |
| Raymond Ventrone | Chartiers Valley | Cleveland |
| Derrick Morgan | Coatesville | Tennessee |
| Mark Herzlich | Conestoga | New York Giants |
| John Kuhn | Dover Area | Green Bay |
| Pat Devlin | Downingtown East | Miami |
| Jahri Evans | Frankford | New Orleans |
| Nate Byham | Franklin | Tampa Bay |
| John Malecki | Franklin Regional | Pittsburgh |
| Justin King | Gateway | Pittsburgh |
| Jameel McClain | George Washington | Baltimore |
| Bernard Pierce | Glen Mills | Baltimore |
| LaRod Stephens-Howling | Greater Johnstown | Arizona |
| Adrian Robinson | Harrisburg | Pittsburgh |
| Nate Eachus | Hazleton Area | Kansas City |
| Player | High School | Pro Team |
| Paul Posluszny | Hopewell | Jacksonville |
| Terrelle Pryor | Jeannette | Oakland |
| Jared Odrick | Lebanon | Miami |
| Vincent Rey | Mercersburg Academy | Cincinnati |
| Chris Snee | Montrose | New York Giants |
| AQ Shipley | Moon Area | Indianapolis |
| Thomas Keiser | North Alleghney | Carolina |
| Brent Grimes | Northeast | Atlanta |
| Barry Church | Penn Hills | Dallas |
| Josh Hull | Penns Valley | St. Louis |
| Jon Condo | Philipsburg-Osceola | Oakland |
| Stefen Wisniewski | Pittsburgh Central Catholic | Oakland |
| Pat McAfee | Plum | Indianapolis |
| Da’Rel Scott | Plymouth-Whitemarsh | New York Giants |
| Mike Cox | Red Land | Atlanta |
| Brandon Fusco | Seneca Valley | Minnesota |
| Don Barclay | Seneca Valley | Green Bay |
| Bruce Gradkowski | Seton-LaSalle | Cincinnati |
| Gino Gradkowski | Seton-LaSalle | Baltimore |
| Reggie Wells | South Park | San Diego |
| Henry Hynoski | Southern Columbia | New York Giants |
| Jordan Norwood | State College | Cleveland |
| Charlie Batch | Steel Valley | Pittsburgh |
| Dan Connor | Strath Haven | Dallas |
| Steven Johnson | Strath Haven | Denver |
| Chris Neild | Stroudsburg | Washington |
| Marques Colston | Susquehanna Township | New Orleans |
| Dom Decicco | Thomas Jefferson | Chicago |
| Lucas Nix | Thomas Jefferson | Oakland |
| Sean Lee | Upper St. Clair | Dallas |
| Toney Clemons | Valley | Jacksonville |
| CJ Davis | West Allegheny | Denver |
| Dorin Dickerson | West Allegheny | Buffalo |
| Matt Schaub | West Chester East | Houston |
| Curtis Brinkley | West Philadelphia | San Diego |
| Dan Koppen | Whitehall | Denver |
| Will Beatty | William Penn (3) | New York Giants |
| Matt Ryan | William Penn Charter | Atlanta |
| Chad Henne | Wilson | Jacksonville |
| Darrin Walls | Woodland Hills | New York Jets |
| Rob Gronkowski | Woodland Hills | New England |
| Ryan Mundy | Woodland Hills | Pittsburgh |
| Shawntae Spencer | Woodland Hills | Oakland |
| Steve Breaston | Woodland Hills | Kansas City |
