District 1
| 11-27 | District 1 | Downingtown East Cougars (10-2) @. Ridley Green Raiders (11-1) | 7:00 pm |
| 11-27 | District 1 | Avon Grove Red Devils (11-1) @. North Penn Knights (12-0) | 7:30 pm |
| 11-28 | District 1 | Interboro Bucaneers (12-0) @. Pottsgrove Falcons (12-0) | 7:00 pm |
| 11-28 | District 1 | St. Pius X Winged Lions (8-4) @. Tri-Valley Bulldogs (8-4) | 7:00 pm |
District 2
| 11-27 | District 2 | Abington Heights Comets (11-1) @. Allentown Central Catholic Vikings (11-1) | 7:00 pm |
| 11-27 | District 2 | Dunmore Bucks (12-0) @. West Catholic Burrs (10-2) | 7:00 pm |
| 11-27 | District 2 | Northwest Area Rangers (9-3) @. Southern Columbia Tigers (8-4) | 7:00 pm |
District 3
| 11-27 | District 3 | Millersburg Indians (9-3) @. Upper Dauphin Trojans (10-1) | 1:00 pm |
| 11-27 | District 3 | Conrad Weiser Scouts (10-2) @. Manheim Central Barons (12-0) | 7:00 pm |
| 11-27 | District 3 | Delone Catholic Squires (11-1) @. Lancaster Catholic Crusaders (11-1) | 7:00 pm |
| 11-27 | District 3 | Cumberland Valley Eagles (10-2) @. Wilson West Lawn Bulldogs (11-1) | 7:00 pm |
| 11-27 | District 3 | West York Bulldogs (11-1) @. Susquehanna Township Indians (11-1) | 7:00 pm |
| 11-28 | District 3 | Penn Manor Comets (10-2) @. Bishop McDevitt Crusaders (11-0) | 1:00 pm |
District 4
| 11-27 | District 6 | Greater Johnstown Trojans (8-3) @. Selinsgrove Seals (12-0) | 7:00 pm |
| 11-27 | District 2 | Northwest Area Rangers (9-3) @. Southern Columbia Tigers (8-4) | 7:00 pm |
| 11-28 | District 4 | Loyalsock Township Lancers (9-3) @. Lewisburg Green Dragons (11-1) | 1:00 pm |
District 11
| 11-27 | District 2 | Abington Heights Comets (11-1) @. Allentown Central Catholic Vikings (11-1) | 7:00 pm |
| 11-28 | District 1 | St. Pius X Winged Lions (8-4) @. Tri-Valley Bulldogs (8-4) | 7:00 pm |
| 11-28 | District 11 | Parkland Trojans (10-2) @. Easton Area Red Rovers (11-1) | 7:00 pm |
| 11-28 | District 11 | Northern Lehigh Bulldogs (10-2) @. North Schuylkill Spartans (12-0) | 7:00 pm |
District 12
| 11-27 | District 2 | Dunmore Bucks (12-0) @. West Catholic Burrs (10-2) | 7:00 pm |
| 11-28 | District 12 | LaSalle Explorers (10-1) @. George Washington Eagles (8-2) | 12:00 pm |
