| 9/15/18 |
| Harrisburg 42, Central Dauphin East 0 |
| 9/14/18 |
| Annville-Cleona 62, Northern Lebanon 13 |
| Bermudian Springs 41, Hanover 0 |
| Biglerville 22, Fairfield 21 |
| Bishop McDevitt 49, Red Land 2 |
| Cedar Crest 35, J.P. McCaskey 21 |
| Central Dauphin 37, Cumberland Valley 7 |
| Cocalico 41, Elizabethtown Area 14 |
| Columbia 25, Pequea Valley 13 |
| Conestoga Valley 20, Lampeter-Strasburg 7 |
| Conrad Weiser 42, Daniel Boone 14 |
| Dallastown 35, South Western 7 |
| Delone Catholic 55, York County School of Technology 0 |
| Donegal 34, Lebanon 12 |
| Dover Area 28, Susquehannock 7 |
| ELCO 21, Octorara Area 14 |
| Gettysburg 42, West York 22 |
| Governor Mifflin 41, Muhlenberg 14 |
| Hamburg 28, Minersville Area 19 |
| Hershey 13, Mechanicsburg 0 |
| Jim Thorpe Area 62, Kutztown 0 |
| Kennard-Dale 27, Big Spring 12 |
| Lancaster Catholic 35, Ephrata 12 |
| Manheim Central 20, Wilson West Lawn 10 |
| Manheim Township 41, Penn Manor 0 |
| Middletown Area 63, Camp Hill 0 |
| Milton Hershey 41, Boiling Springs 27 |
| Northeastern 35, Spring Grove 21 |
| Northern York 20, Mifflin County 13 |
| Palmyra 28, East Pennsboro 21 |
| Red Lion Area 56, Central York 28 |
| Shippensburg Area 28, Waynesboro 20 |
| Solanco 48, Garden Spot 21 |
| Steelton-Highspire 35, Trinity 14 |
| Susquehanna Township 34, Lower Dauphin 7 |
| Susquenita 29, Williams Valley 7 |
| Twin Valley 28, Reading 9 |
| Upper Dauphin 29, Newport 26 |
| Warwick 27, Hempfield 0 |
| West Perry 49, Greencastle-Antrim 20 |
| William Penn (3) 71, New Oxford 14 |
| York Catholic 22, Littlestown 19 |
| York Suburban 49, Eastern York 7 |
