| 10/20/18 |
| Columbia-Montour Vo-Tech 36, Holy Cross 14 |
| Midd-West 59, Vincentian Academy 0 |
| 10/19/18 |
| Bald Eagle Area 24, Jersey Shore 23 |
| Central Columbia 42, Lewisburg 16 |
| Central Mountain 28, Mifflinburg 21 |
| Danville 31, Selinsgrove 7 |
| Loyalsock Township 36, Warrior Run 0 |
| Montgomery 34, Cowanesque Valley 0 |
| Montoursville 49, Towanda 13 |
| Mount Carmel Area 53, Bloomsburg 0 |
| North Penn/Mansfield 25, Canton Area 22 |
| Sayre 28, Muncy 14 |
| Shamokin 34, Shikellamy 0 |
| South Williamsport 21, Milton Area 14 |
| Southern Columbia 69, Hughesville 8 |
| Tri-Valley 27, Line Mountain 14 |
| Troy Area 21, Athens 0 |
| Wallenpaupack 36, Williamsport 17 |
| Wellsboro 49, Wyalusing Area 22 |
