| 9/8/18 |
| Nativity BVM 21, Columbia-Montour Vo-Tech 14 |
| 9/7/18 |
| Berwick Area 41, Williamsport 17 |
| Bloomsburg 28, North Penn/Mansfield 7 |
| Canton Area 45, Wyalusing Area 20 |
| Central Columbia 42, Lehighton 7 |
| Danville 38, Warrior Run 20 |
| Jersey Shore 30, Montoursville 20 |
| Loyalsock Township 35, Shikellamy 0 |
| Mifflinburg 32, Milton Area 0 |
| Mount Carmel Area 40, Lewisburg 20 |
| Muncy 15, Towanda 14 |
| Shamokin 35, Central Mountain 6 |
| South Williamsport 54, Hughesville 22 |
| Southern Columbia 48, Selinsgrove 0 |
| Troy Area 20, Sayre 7 |
| Wellsboro 33, Montgomery 7 |
| 9/6/18 |
| Athens 43, Cowanesque Valley 13 |
