District 1
| 11-20 | District 1 | Unionville Indians (8-3) @. Ridley Green Raiders (10-1) | 7:00 pm |
| 11-20 | District 1 | Sun Valley Vanguards (0-10) @. Haverford Township Fords (3-6) | 7:00 pm |
| 11-20 | District 1 | Bayard Rustin Golden Knights (11-0) @. Pottsgrove Falcons (11-0) | 7:00 pm |
| 11-20 | District 1 | St. Pius X Winged Lions (7-4) @. Calvary Christian Academy Cougars (8-1) | 7:00 pm |
| 11-20 | District 1 | Avon Grove Red Devils (10-1) @. Downingtown West Whippets (10-1) | 7:00 pm |
| 11-20 | District 1 | Owen J. Roberts Wildcats (10-1) @. Interboro Bucaneers (11-0) | 7:30 pm |
| 11-20 | District 1 | Neshaminy Redskins (9-2) @. North Penn Knights (11-0) | 7:30 pm |
| 11-21 | District 1 | Penncrest Lions (8-3) @. Downingtown East Cougars (9-2) | 7:00 pm |
District 2
| 1-20 | District 2 | Hazleton Area Cougars (8-3) @. Easton Area Red Rovers (10-1) | 7:00 pm |
| 11-20 | District 2 | Hanover Area Hawkeyes (6-5) @. Mount Carmel Area Red Tornadoes (6-5) | 7:00 pm |
| 11-20 | District 2 | Riverside Vikings (4-7) @. Northwest Area Rangers (8-3) | 7:00 pm |
| 11-20 | District 2 | Lakeland Chiefs (8-3) @. Dunmore Bucks (11-0) | 7:00 pm |
| 11-21 | District 2 | Dallas Mountaineers (10-1) @. Abington Heights Comets (10-1) | 1:00 pm |
District 3
| 11-20 | District 3 | Cocalico Eagles (9-2) @. Susquehanna Township Indians (10-1) | 7:00 pm |
| 11-20 | District 3 | Cumberland Valley Eagles (9-2) @. Central Dauphin Rams (9-2) | 7:00 pm |
| 11-20 | District 3 | Daniel Boone Blazers (9-2) @. Manheim Central Barons (11-0) | 7:00 pm |
| 11-20 | District 3 | Conestoga Valley Buckskins (7-4) @. West York Bulldogs (10-1) | 7:00 pm |
| 11-20 | District 3 | Littlestown Thunderbolts (9-2) @. Delone Catholic Squires (10-1) | 7:00 pm |
| 11-20 | District 3 | Penn Manor Comets (9-2) @. South Western Mustangs (10-1) | 7:00 pm |
| 11-20 | District 3 | York Catholic Fighting Irish (7-4) @. Upper Dauphin Trojans (9-1) | 7:00 pm |
| 11-20 | District 3 | Millersburg Indians (8-3) @. Steelton-Highspire Steamrollers (8-2) | 7:00 pm |
| 11-20 | District 3 | Middletown Area Blue Raiders (8-3) @. Lancaster Catholic Crusaders (10-1) | 7:00 pm |
| 11-20 | District 3 | Hershey Trojans (9-2) @. Conrad Weiser Scouts (9-2) | 7:00 pm |
| 11-20 | District 3 | Central York Panthers (8-3) @. Wilson West Lawn Bulldogs (10-1) | 7:00 pm |
| 11-21 | District 3 | Governor Mifflin Mustangs (7-4) @. Bishop McDevitt Crusaders (10-0) | 1:00 pm |
District 4
| 11-20 | District 4 | Shikellamy Braves (7-4) @. Selinsgrove Seals (11-0) | 7:00 pm |
| 11-20 | District 4 | Lewisburg Green Dragons (10-1) @. Towanda Black Knights (11-0) | 7:00 pm |
| 11-20 | District 4 | Muncy Indians (6-5) @. Shenandoah Valley Blue Devils (6-5) | 7:00 pm |
| 11-20 | District 4 | Southern Columbia Tigers (7-4) @. Line Mountain Eagles (8-3) | 7:00 pm |
| 11-20 | District 4 | Loyalsock Township Lancers (8-3) @. Hughesville Spartans (10-1) | 7:00 pm |
District 11
| 11-20 | District 11 | Whitehall Zephyrs (6-5) @. Emmaus Hornets (6-5) | 7:00 pm |
| 11-20 | District 11 | Wilson Area Warriors (11-0) @. Allentown Central Catholic Vikings (10-1) | 7:00 pm |
| 11-20 | District 11 | Catasauqua Rough Riders (8-3) @. Northern Lehigh Bulldogs (9-2) | 7:00 pm |
| 11-20 | District 11 | Parkland Trojans (9-2) @. East Stroudsburg South Cavaliers (10-1) | 7:00 pm |
| 11-20 | District 11 | Bethlehem Catholic Golden Hawks (6-5) @. Northwestern Lehigh Tigers (8-3) | 7:00 pm |
| 11-21 | District 11 | Tri-Valley Bulldogs (7-4) @. Pius X Royals (9-2) | 1:00 pm |
| 11-21 | District 11 | Panther Valley Panthers (9-2) @. North Schuylkill Spartans (11-0) | 7:00 pm |
District 12
| 11-20 | District 12 | LaSalle Explorers (9-1) @. Saint Joseph’s Prep Hawks (9-1) | 7:00 pm |
| 11-21 | District 12 | West Catholic Burrs (9-2) @. Edward Bok Vo-Tech Wildcats (10-0) | 12:00 pm |
| 11-21 | District 12 | Archbishop Wood Vikings (9-2) @. Simon Gratz Bulldogs (7-4) | 4:00 pm |
