| Aliquippa 48, McKinley Tech (DC) 0 |
| Bedford 29, Westmont Hilltop 28 |
| Bishop Guilfoyle 17, Somerset Area 0 |
| Bishop McDevitt 42, Philadelphia Central 7 |
| Canton Area 25, Towanda 21 |
| Cardinal Wuerl North Catholic 49, Albert Gallatin 12 |
| Carlynton 34, Bishop Canevin 7 |
| Coatesville 37, Harrisburg 6 |
| Conemaugh Valley 52, North Star 6 |
| Conwell-Egan Catholic 38, Roman Catholic 20 |
| Elizabethtown Area 49, Donegal 33 |
| Haverford High 26, Chester 12 |
| Holy Cross 14, Holy Redeemer 12 |
| Imani Christian Academy 80, Richard Wright Charter School (D.C.) 6 |
| Manheim Township 17, Central Dauphin East 10 |
| McKeesport Area 45, Erie HS 26 |
| Mercer Area 21, Cochranton 6 |
| Northern Lehigh 34, Wilson Area 18 |
| Pen Argyl 17, Salisbury Township 16 |
| Quakertown Community 20, Central Bucks East 13 |
| Smethport Area 54, Sheffield Area 6 |
| South Side Area 28, Sto-Rox 26 |
| Susquehanna Community 33, Wilkes-Barre G.A.R. 24 |
| Tyrone 16, Bellwood-Antis 7 |
| Union Area 35, Shenango 20 |
| Western Beaver 30, Summit Academy 0 |
| Wyomissing Area 49, Twin Valley 14 |
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